Policosanol is a well-tolerated mixture of long-chain aliphatic alcohols derived from sugar cane wax. It promotes: - healthy lipid metabolism, - triglyceride support, - platelet function, and - antioxidant protection for cardiovascular health.*
Lipid And Cardiovascular Support: The promising results of randomized, double blind placebo-controlled trials, including comparative studies, suggest that policosanol supports cardiovascular health.
Though the mechanism for cardiovascular support of this substance remains unclear, policosanol may act in part by providing antioxidant protection, promoting healthy platelet function, and supporting healthy lipid metabolism.
Over a decade of short-term and long-term clinical research involving thousands of subjects reveals the safety and tolerability of policosanol. At the highest dosage recommended by Pure Encapsulations, policosanol may support healthy triglyceride metabolism in some individuals.
What Is The Source?
Policosanol is derived from sugar cane wax.Hypo-allergenic plant fiber is derived from pine cellulose.
Pure Encapsulations recommends 10-40 mg per day, in divided doses, with meals.
Are There any Side Effects Or Precautions?
At this time, there are no known side effects or precautions. If pregnant or lactating, consult your physician before taking this product.
Are There Any Potential Drug Interactions?
Policosinol supports healthy platelet function and may act synergistically with blood-thinning drugs.
How to Help Lower your Cholesterol Naturally
Diet: Try to eliminate high-cholesterol foods from your diet.These are generally foods containing oils and fats. Exercise: Cardio has been shown to lower cholesterol.If you do not currently have an exercise plan, try to get at least 3 sessions of 30 minutes of exercise (brisk walking, swimming, etc) each week. Special Foods: Some foods, such as nuts and oatmeal, are actually found to lower cholesterol. Weight loss: This generally goes along with eating better and exercising, but weight loss also contributes to lowering cholesterol.
Serving Size 1 Vegetable Capsule, Servings Per Container 120
Policosanol has proven equivalent to or better than several statin drugs like imvastatin, pravastatin, lovastatin, probucol, or acipimox in reducing cholesterol levels in patients with hypercholesterolemia, and has fewer side effects.
This dietary supplement also decreases several other risk factors for CHD by decreasing the oxidation of LDL cholesterol, platelet aggregation, endothelial damage, and smooth-muscle-cell proliferation.
Fifteen double-blind, placebo-controlled trials, ranging in duration from 6 weeks to 12 months and collectively involving more than 1,000 subjects, have found policosanol to be effective for lowering total and LDL cholesterol, the ratio of LDL to HDL cholesterol, and the ratio of total cholesterol/ to HDL cholesterol.
Most of these trials have been done at the Surgical Medical Research Center in Havana, Cuba with policosanol derived from Cuban sugar cane. One randomized, double-blind, placebo-controlled trial examined the effects of 5 to 10 mg of policosanol per day for 12 months on the lipid profile of 589 older patients with hypertension and type II hypercholesterolemia, and without a history of congestive heart disease. The study found that policosanol improved all parameters of the lipid profile with great statistical significance.
A number of comparative studies have been done of policosanol versus commonly prescribed statin drugs. In one such study in which policosanol was tested against pravastatin over an 8-week period in an older population with hypercholesterolemia, it proved more effective at improving all lipid profile markers, and with a high degree of statistical significance. In another study, comparing policosanol at 10 mg/day with atorvastatin at 10 mg/day, the latter was slightly more effective than policosanol at reducing total cholesterol, while policosanol was more effective at raising HDL cholesterol, by 5.3% vs. no increase with atorvastatin, without any reported adverse reactions.
The American Heart Journal evaluated the peer-reviewed literature on placebo-controlled lipid-lowering studies using policosanol and found that at doses of 10 to 20 mg/day, policosanol reduced both total and LDL cholesterol while raising HDL cholesterol.
The Journal further stated that at dosages of up to 20 mg/day, policosanol is safe and well tolerated. The study concluded that policosanol is a "very promising phytochemical alternative to classic lipid-lowering agents such as the statins, and deserves further evaluation."
The usual dosage of policosanol is from 5 to 20 mg twice daily. Cautions include possible adverse reactions including migraine, insomnia, dizziness, irritability, stomach upset, and skin rash. Since policosanol can inhibit platelet aggregation, it may have an additive interactive effect with antiplatelet and anticoagulant drugs. Its concomitant use with these drugs may also theoretically increase bruising and bleeding.
Also, policosanol can reduce blood pressure and may enhance this effect of beta-blocker drugs. Its concomitant use with the latter drugs therefore requires careful and regular monitoring of blood pressure.