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Crohn's Disease- Pathophysiology and Conventional and Alternative Treatment Options

Crohn's Disease

Table 1: Subcategories of Crohn's Disease

Table 2: Signs and Symptoms of Crohn's Disease and Ulcerative Colitis

Risk Factors



  1. The Genetic Component of Crohn's Disease
  2. Stress in the Etiology of Crohn's Disease
  3. Microbial Factors
  4. Inflammation/Immune Response
  5. Intestinal Permeability
  6. Other Abnormalities Contributing to the Etiopathogenesis of Crohn's Disease

Conventional Treatment of Crohn's Disease

Table 5: Conventional Medications and their Mechanisms in Crohn's Disease

Nutrient Deficiences in Crohn's Disease

Table 6: nutrient Deficiencies Associated with Crohn's Disease

Dietary Interventions in Crohn's Disease

Table 7: Diet Therapies Compared to Steroid Medications in Crohn's Disease

Probiotics in the Treatment of Crohn's Disease

Fatty Acids for the Treatment of Crohn's Disease

Table 8: A Summary of Omega-3 Fatty Acid Studies in Crohn's Disease


N-acetyl Glucosamine

Remicade Increasing Risk of Cancer

Botanicals in the Treatment of Crohn's Disease

Dehydroepiandrosterone (DHEA)

Potential Sequelae of Crohn's Disease


Table 6. Nutrient Deficiencies Associated with Crohn’s Disease Nutrient

Nutrient Status Daily Recommendation (adult)
Vitamin A Deficient 5,000-25,000 IU; not to exceed 7500 iu in pregnancy
Beta-carotene Deficient 25,000-1,000,000 natural mixed cis/trans beta-carotene
Vitamin D Deficient 400-800 IU
Vitamin E Deficient 400-800 IU
Vitamin K Deficient 500 mcg-1 mg
Vitamin C Deficient 500-1,000 mg
Vitamin B1 (thiamine Deficient 100 mg
Vitamin B2 (riboflavin) Deficient 100 mg
Vitamin B3 (niacin) Deficient 100 mg
Vitamin B12 Deficient 1 mg
Folic Acid Deficient 400-800 mcg
Biotin Deficient 300 mcg-1 mg
Calcium Deficient 1,000 mg
Magnesium Deficient 500 mg
Iron Deficient in serum; elevated in gut mucosa Supplement with 50-70 mg daily well-absorbed form only in anemic; otherwise avoid supplementation
Zinc Deficient 15-30 mg
Copper Elevated Avoid unless supplementing with >15 mg zinc for long period of time; then supplement with 1-2 mg
Selenium Deficient 200-400 mcg


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