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Probiotics Symposium San Antonio, TX. Oct 24th, 2013

I flew in to San Antonio Texas last night for the 7th Annual Probiotics Symposium, held at Embassy Suites on the River Walk, sponsored by the The Institute of Medical Studies and supported by an educational grant from Klaire Labs. I’m happy to say that I have attended them all, knowing that they provide us with the latest development in the use of probiotics in clinical practice. San Antonio RiverWalk

The plane from Phoenix to San Antonio was a small one, so the attendants took our ‘rollies’ at the entrance to the plane to store in the hold as they would not fit in the overhead compartments. When we got to San Antonio, we waited at the plane entrance for our ‘rollies’ to arrive. To my horror, I watched a lady grab my suitcase and quickly walk away, wheeling my luggage, instead of her own, and, I was unable to catch up to her in time to stop her. The good news is that her phone number was clearly marked on her luggage, which was the only one left, unclaimed. The phone call was made and she immediately came back to the airport so we could exchange cases. It made me wonder if this was some kind of omen… I was truly grateful for the outcome!

The Symposium started off with a ‘pre-symposium day’ of information, presented by Dr Stephen Olmstead, Chief Science Officer for Prothera Inc and David Quig, PhD VP Scientific Support from Doctor’s Data Labs.

Dr Olmstead is very knowledgeable about probiotics and the role they play in keeping us healthy. He also gave us lots of incredibly detailed information about of the role of pathogen-associated biofilm dysbiosis in our bodies, the biofilm being the place where very often, candida and other pathogenic organisms, may hide out, often for long periods of time, and why it’s so difficult to get rid of the problems that arise as a result of their mere existence. Its fascinating to learn how innately ‘intelligent’ pathogen-associated biofilm is, and what’s more, it’s not that the concept of biofilm is new. We have known about biofilm every since we knew that microbiota even existed, however, its only recently that we are discovering how biofilm functions. Dr Olmstead recommended including 2 enzyme products that he formulated, Interfase and Interfase Plus, to be used in any protocol to break down pathogenic biofilm in the gut. (If you’d like to order Interfase or Interfase Plus – let us know by sending us a message –
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Talking about probiotics, he stressed how the normal central nervous system needs gut flora to develop. He stressed how probiotics protect us from pathogens, regulate our immune response and also give us nutritional support. Of course, it all starts with mom … the maternal probiotics are delivered to breast milk and then to the infant; so if Mom is healthy, that’s all the infant would need. Probiotics in mother’s milk is mainly made up of bifidus, so that’s why its always a good idea to supplement with bifidus for infants and kids struggling to get rid of any digestive complaints.

Dr Olmstead reminded us the term acidophilus had been used for a long time to refer to any probiotics and it was only in the 1970’s that it was reclassified. We know that this particular strain of lactobacillus is resistant to bile acids, helps break down casein and gluten and also keeps pathogens away.

He spoke, too, about Bacillus, the Gram-positive aerobes. We used to think that they were not part of microbiota, but now we know they are. They can actually function as anaerobes if need be. They are soil based organisms and are spoken about as ‘transient commensals’ as they are only in the gut for a short time. But, even though they are in the gut for a short time, they can be very effective in getting rid of bad bacteria (pathogens).

Dr Olmstead mentioned how probiotics were not regarded as very effective in treatment with IBD, even though, in his opinion, they are extremely effective. I was thrilled to hear that, as, in my private practice and managing Crohns.net as an e-commerce site for purchase and education about probiotics for the past 15 years, I know, too, from my clinical practice and experience that probiotics, have helped tens of thousands of patients world wide.

Probiotics are one of the key supplements included in my suggested protocol to deal with the signs and symptoms of Crohns disease and Ulcerative colitis. Olmstead mentioned that he found s boulardii particularly helpful in probiotic combinations for Crohn’s Disease patients. This is verified by clinical studies (Campieri et al 2000, 118, 781).  He also mentioned studies done by Gionchetti (2000 and 2003) and Mimura (2004) using VSL#3 probiotics that were very effective in reducing the number of relapses of pouchitis.

IMG_20131024_171806_328It was delightful to meet Dr Josephine Ruiz-Healy M.D. a local, San Antonian Integrative Pediatric physician who shared how her dad had been a surgeon practicing in Mexico and how she was introduced to integrative alternatives by him. She uses probiotics in her practice all the time.

More to come tomorrow!

 

‘Pouchitis’ after ulcerative colitis surgery linked to changes in gene expression

I read a very interesting article that talks about how genes change after Pouchitis surgery – isn’t that fascinating

pouchitis

Pouchitis developing after surgery for ulcerative colitis (UC) is associated with changes in gene expression, which increase along with disease severity, reports a study in Inflammatory Bowel Diseases, official journal of the Crohn’s & Colitis Foundation of America (CCFA). The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

“Gene alterations in pouch inflammation and Crohn’s disease overlap, suggesting that inflammatory bowel disease is a spectrum, rather than distinct diseases,” according to the new research by Dr S. Ben Shachar and colleagues of Tel Aviv University, Israel. They believe the occurrence and progression of gene changes in previously normal intestine after UC surgery provides a useful model for studying the development of inflammatory bowel disease (IBD).

After UC Surgery, Gene Expression Changes in Patients with “Pouchitis”

he researchers analyzed gene expression changes in different groups of patients who had undergone “pouch” surgery for UC. In this procedure (restorative proctocolectomy), the entire large intestine is removed and a portion of small intestine (the ileum) is used to create a reservoir, or pouch, to restore bowel function.

Up to one-fourth of patients with UC need surgery because of unmanageable disease or complications. Surgery is effective, but has a substantial rate of complications—especially the development of inflammation in the newly created pouch, called pouchitis.

By definition, the small intestine is normal in UC—in contrast to Crohn’s disease (CD), which can affect any part of the gastrointestinal tract. The development of pouchitis after UC surgery thus provides an opportunity to study the “molecular events” associated with the development of IBD in previously normal tissue.

The researchers found no significant changes in gene expression in normal samples of ileum from patients with UC. In contrast, in patients who had undergone UC surgery, nearly 170 significant changes in gene expression were found in samples of tissue from the surgically created pouch—even though the tissue still appeared normal.

In patients who had developed inflammation and other signs of pouchitis, the number of gene abnormalities increased to nearly 500. For those who progressed to develop “Crohn’s-like” changes of the pouch tissue, the number of gene abnormalities increased to well over 1,000. Thus as the severity of pouch disease increased, so did the number of gene expression changes.

VSL#3

VSL#3

Vsl#3 (one of the most potent probiotics on the market) research shows how taking these probiotics on a daily basis will reduce occurrence on pouchitis.

Source: Wolters Kluwer Health

Ulcerative Colitis surgery helped with Probiotics

Studies show that Ulcerative Colitis patients who have their colons removed are less likely to develop complications if treated with probiotics.

Removal of the colon, and connection of the small intestine to the rectum, cuts out the inflamed portion and relieves symptoms. But often a complication, called pouchitis, occurs, which is often associated with increased stool frequency, rectal bleeding, pain and fever.

Scientists doing research on Ulcerative Colitis patients at the University of Bologna, Italy, have found that giving patients a dose of probiotics – ‘friendly’ bacteria that help colonize the gut in a healthy way – reduces the risk of pouchitis after surgery. The daily packet of bacteria contained 900 billion organisms, consisting of four strains of Lactobacillus , three strains of Bifidobacterium and one of Streptococcus salivarius . Just ten per cent of those on probiotics developed pouchitis, compared to 40 per cent of those on placebo.

After Ulcerative Colitis surgery, pouchitis is normally treated by antibiotics. However, if it becomes chronic, the patient may be faced with long-term treatment, which raises the threat of side effects and resistance. Probiotic treatment looks like a much better option, according to this study.

Ulcerative Colitis affects the large intestine (colon) and the rectum. It causes inflammation of the colon’s inner lining and the rectal wall. The wall becomes red, swollen, and ulcerated, resulting in abdominal pain or cramping, rectal bleeding, whitish mucus, and diarrhea.

Less common are fatigue, appetite loss, and anemia. Some people also have joint pain, redness, swelling, and liver problems

Ulcerative Colitis

Ulcerative Colitis

Ulcerative Colitis Signs and Symptoms

Ulcerative Colitis patients experience mild symptoms. Be sure to consult your doctor if you experience any of the following symptoms:

  • bowel movements become looser and more urgent
  • persistent diarrhea accompanied by abdominal pain and blood in the stool
  • stool is generally bloody
  • cramp abdominal pain

People suffering from Ulcerative Colitis often experience loss of appetite and may lose weight as a result. A feeling of low energy and fatigue is also common. Among younger children, Ulcerative Colitis may delay growth and development.

The symptoms of Ulcerative Colitis do tend to come and go, with fairly long periods in between flare-ups in which patients may experience no distress at all. These periods of remission can span months or even years, although symptoms do eventually return. The unpredictable course of Ulcerative Colitis may make it difficult for physicians to evaluate whether a particular course of treatment has been effective or not.

Did you know that Ulcerative Colitis can improve with alternative therapies like natural supplements, diet, stress release and others?

Ulcerative Colitis Alternative Therapies:
Many people with inflammatory bowel diseases, Ulcerative colitis and Crohn’s disease, have used some form of alternative or complementary therapy.

probiotics

  • Probiotics. Because bacteria in the intestine have been implicated in ulcerative colitis, researchers suspect that adding more of the beneficial bacteria (probiotics) that are normally found in the digestive tract might help combat the disease.
  • Fish oil. Fish oil acts as an anti-inflammatory. IBD patients are helped by reducing inflammation in the digestive tract.

    Aloe vera. Aloe vera juice has been purported to have an anti-inflammatory effect for people with ulcerative colitis,. In addition, aloe vera can have a natural laxative effect.

    FYI — For Your Inflammation –  FYI is a blend of 15 potent Foods, Enzymes, and Botanicals and contains naturally occurring cartilage building compounds such as Mucopolysaccharides and Chondroitin Sulfate

 

 

 

 

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