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Genova’s GI Effects Stool Test is the Best

I’m sold on Genova Lab’s GI Effects Stool Test.  It really is the best …and I’ll tell you why.

I’ve been using this lab for over 30 years now, if you can believe that.  They’ve really made great strides in staying up-to-date by including state-of the-art testing options in this test. I started using GI Effects profile a lot recently and find it to be extremely informative.

In previous years, their stool tests that  I ran for my patients were cultures only. Now they make use of PCR testing as well. You see anaerobic organisms don’t grow in culture, so having DNA testing is far more accurate.

What is PCR testing?

DNA Sequencing used in GI Effects Stool test
PCR stands for Polymerase Chain Reaction.

It is used to amplify selected sections of DNA or RNA for analysis. Previously, this procedure required cloning of the segments of interest into vectors for expression in bacteria. It took weeks.

But now, PCR is done in test tubes. It only takes a few hours. This means that this advanced stool test is able to provide immediate, actionable clinical information.

It helps in evaluating the course of action needed to manage various types of gut conditions like irritable Bowel Syndrome IBS, Crohns, Colitis IBD and other Malabsorption Disorders

Their PCR molecular assay is optimized for stool testing. It assesses 24 commensal bacteria associated in scientific literature with health and disease. It gives us valuable insight into the human microbiome.

I’m also very impressed by the enhanced test reporting that they do. On the very first page there’s an overview that you can understand at a glance. It highlights biomarkers in three main areas of gut health: Infection, Inflammation, and Metabolic Imbalance. This makes it very easy for lay people to understand and to see what areas need attention.

I also like that the GI Effects Comprehensive Profile includes very important markers:

(a) Calprotectin.
This is an invaluable biomarker that can effectively differentiate between Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD).

(b) Ova & Parasite Detection.
They use the gold standard for parasite identification.

You can choose as to whether you want a 1 or 3 day collection, based on how likely there is an issue relating to parasitic infection.

If low or no suspicion of parasites, then a one day sample is adequate.

Only if there is a high likelihood of parasites that a 3-day sample collection is needed.

Add-On Options to GI Effects Stool Test

I like the way they make certain valuable add-ons available.

Some pathogenic bacteria testing can be extremely expensive. So, by excluding them in the original test, but offering them as ‘add-on’s’ is a great idea.

The specific bacteria add-on tests that can be run are:

  • Clostridium difficile,
  • Campylobacter,
  • Escherichia coli EIA,
  • Helicobacter pylori EIA and
  • Fecal Lactoferrin.

Zonulin Tests for Intestinal Permeability

Their most recent add-on is Zonulin.

Zonulin is a protein modulator of intestinal tight junctions that is used to assess intestinal permeability.

Up until now, the only way we could test for intestinal permeability was by using a stand alone test … another expense and not a very pleasant procedure.

We had to drink pre-measured amounts of lactulose and mannitol and then evaluate the degree of intestinal permeability or malabsorption that was reflected in the levels of the two sugars recovered in a urine sample that needed to be collected over the next 6 hours.

We know from recent peer-reviewed literature about the significant role that intestinal permeability plays in many chronic gut problems, particularly Leaky Gut with symptoms like bloating, gas and cramps.

Intestinal Permeability will also have an impact on IBS, food sensitivities, joint pains, skin rashes and auto immune conditions.

Then there’s added problems associated with intestinal permeability for Cardio-metabolic diseases like type 1 and 2 diabetes, obesity, non-alcoholic fatty liver disease, and even insulin resistance.

Being able to add the Zonulin test on to the GI Effects Profile is a win. One less test, added financial savings and less hassle.

 

Dysbiosis Testing and Treatment

Gut Dysbiosis – Test, Treat & Feel Better

Test now for Dysbiosis with Genova Intestinal Permeability home test

Genova Intestinal Permeability Home Urine Test

Use this simple test, which is delivered directly to your home from Genova Labs to help you understand whether your digestive complaints are related to dysbiosis or not.

Dysbiosis can present with a wide variety of symptoms. This is an excellent, easy way to gain more information about how well your intestines are functioning.

The test analyzes urine for the clearance of two sugars that are not metabolized. They are called lactulose and mannitol. How these two sugars clear as well as the ratio between them, helps to identify dysbiosis. Dysbiosis is also referred to, ‘leaky gut syndrome’ and malabsorption.

Here are some recommended supplements for Dysbiosis:

What is Dysbiosis?

Dysbiosis means there is an overgrowth of yeast, harmful bacteria, viruses or parasites in the intestines.

Dysbiosis is merely a more general term relating to an overgrowth of pathogens. Yeasts are not the only intestinal residents that may cause these symptoms. In fact, intestinal bacteria or viruses are often the culprits and not yeast. Severe dysbiosis sufferers will have overgrowth of both fungus and pathogenic bacteria in their intestines.

Dr. Metchinkoff, a Russian Scientist, was the one to popularize the idea of “Dys-symbiosis, or Dysbiosis,” which is a state of living with intestinal flora that have harmful effects. He suggested that toxic amines produced by bacterial putrefaction of food were the cause of degenerative diseases, and that by eating fermented foods containing Lactobacilli we could prolong life by reducing gut putrefaction. The thought of dysbiosis with digestive flora as an influence in the way inflammatory diseases and cancer develops, has received considerable experimental support over the past twenty years.

Symptoms of Dysbiosis

Dysbiosis does more than interfere with digestion, it makes you tired. Dysbiosis also alters your immune system and upsets your hormonal balance. Dysbiosis can even make it difficult for you to think clearly. It is known to cause anxiety, depression or mood swings. In fact, dysbiosis can affect almost every aspect of health.

If you have dysbiosis, then you are likely to suffer from fatigue, headaches, intestinal upsets, and many of the symptoms normally thought of to be associated with Candida.

What causes Dysbiosis?

Changes in the ratios of the gut flora may lead to disease. Bacterial enzymes can also alter the intestinal environment in many ways, some of which can be easily measured in a properly collected sample of stool and evaluated by Genova Lab. Bacterial antigens may cause dysfunctional immune responses that encourage autoimmune diseases of the bowel and of connective tissue. Effective treatment of dysbiosis may be achieved with diet and anti-microbial supplements.

Sometimes, changes in diet and using probiotics do not help to reduce symptoms. This may mean that there is small bowel bacterial overgrowth, which is a disorder that demands a different approach.

Based on available research and clinical data, generally there are four causes of dysbiosis: intestinal putrefaction, fermentation, deficiency and sensitization.

  1. Putrefaction

    Putrefaction dysbiosis results from diets high in fat and animal flesh and low in insoluble fiber. You can help this kind of dysbiosis by decreasing dietary fat and flesh, increasing fiber consumption and taking Bifidobacteria and Lactobacillus probiotics.When there is a decrease in probiotics, or friendly bacteria, the production of short-chain fatty acids and other beneficial nutrients is reduced. There is also an increase in ammonia which can have negative effects on many bodily functions. Research suggests that this type of dysbiosis is contributing towards colon cancer and breast cancer.
  2. Fermentation (Small Bowel Bacterial Overgrowth)

    This is a condition of overgrowth of bacteria in the stomach, small intestine and beginning of the large intestine and causes carbohydrate intolerance.This may be the only symptom of bacterial overgrowth, making it very difficult to distinguish it from intestinal candidiasis.Gastric bacterial overgrowth increases the risk of systemic infection. British physicians who have been researching gut-fermentation syndrome think that, based on treatment results, the majority of cases are due to overgrowth and about 20% are bacterial in origin. The symptoms include abdominal distension, carbohydrate intolerance, fatigue and impaired mental function.

    Bacterial overgrowth here is encouraged by:

    • hypochlorhydria or low stomach acid
    • sluggishness due to abnormal bowel motility,
    • immune deficiency or
    • by malnutrition.

    Its important to understand that bacterial overgrowth in the intestines, increases the risk of systemic infection and can lead to intolerance to carbohydrates. Any carbohydrate that are eaten are fermented by bacteria and this results in toxic waste products being produced.

    Dietary sugars can be fermented to produce ethanol.
    Chronic exposure of the small bowel to ethanol may increase intestinal permeability.

  3. Deficiency

    Taking antibiotics or eating a diet low in soluble fiber may create a deficiency of normal friendly flora, i.e. BifidobacteriaLactobacillus and E.Coli. This condition has been described in patients with Irritable Bowel Syndrome (IBS) and food intolerance. Deficiency and putrefaction dysbiosis are complementary conditions which often happen at the same time and call for the same treatment regime.
  4. Sensitization 

    Aggravation of abnormal immune responses to aspects of the normal intestinal flora may add to the development of Inflammatory Bowel Disease (Crohn’s Disease and Ulcerative Colitis), spinal arthritis and other connective tissue disease and skin disorders such as psoriasis or acne.

Recommendations for Putrefaction and Fermentation Dysbiosis

For putrefaction dysbiosis a diet high in both soluble and insoluble fiber and low in saturated fat and animal protein is recommended.

These dietary changes help to lower the concentrations of Bacteroides and also increase concentrations of lactic acid-producing bacteria like Bifidobacteria, Lactobacillus and beneficial lactic acid streptococcus in the colon.

For fermentation dysbiosis, on the other hand, starch and soluble fiber can exacerbate the abnormal gut ecology. When the small intestine is involved, simple sugars are also not advisable. A diet free of cereal grains and added sugar is recommended.

Fruit, fat and starchy vegetables are tolerated to variable degree for each individual. Oligosaccharides found in some vegetables, carrots in particular, inhibit the binding of enterobacteria to the intestinal mucosa.

Make the necessary dietary changes to help keep your symptoms under contol

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