The investigators have shown preliminary clinical evidence that children with Autism Spectrum Disorder as well as Gastro-Intestinal symptoms differ in the composition of their microbiome and function from children not displaying or characterized by autistic or other neurologically atypical patterns of thought or behavior who also have GI symptoms.
The investigators suspect that altered host-microbial signals that include altered fecal neurotransmitter gamma-aminobutyric acid (GABA) levels contribute towards anxiety and sensory over-responsivity in kids with Autism Spectrum Disorder.
Visbiome Probiotic Pilot Study
Their preliminary findings also showed that administration of probiotic Visbiome Extra Strength, improves GI and pain symptoms, correlating with altered gut microbiome composition and related metabolites (the macrobiome).
This proposed cross-over trial is looking to explore the possibilities of a new understanding of the microbiome and the mental/physical function connection for Autism Spectrum Disorder, Gastro-Intestinal dysfunction, and anxiety. If altering the gut microbiome leads to better GI and emotional function, it may be able to improve the quality of life for children with Autism Spectrum Disorder and their parents.