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Reg’Activ Lactobacillus Fermentum ME-3 Reduce Cardiac Risk

Lactobacillus Fermentum ME-3 Research Reduces Cardiac Risk

A research study was published in the British Journal of Nutrition in 2003 to show how Lactobacillus Fermentun ME-3 reduces Cardiac risk.

Title:
Antioxidative probiotic fermented goats’ milk decreases oxidative stress-mediated atherogenicity in human subjects

Journal: British Journal of Nutrition. 2003; Vol. 90; pp.449-456. Authors: Tiiu Kullisaar, Epp Songisepp, Marika Mikelsaar, Kersti Zilmer, Tiiu Vihalemm, and Mihkel Zilmer

Subjects: Twenty-one healthy subjects (aged 35-65) divided into 2 groups.

Study Design:
During the 3-week study, 16 participants consumed 150 grams of goats’ milk fermented with Lactobacillus fermentum ME-3 (test group) while 5 participants ingested 150 g fresh goats’ milk without probiotics (control group).

Testing:
Blood and urine samples
were initially tested and then again at the end of the 3-week trial. Blood was analyzed for total antioxidant activity (TAA), total antioxidant status (TAS), ratio of oxidized to reduced glutathione, oxidized LDL-cholesterol and 8- isoprostanes (measure of free radical damage to unsaturated fatty acids). Also, fecal samples were collected at the beginning (day 0) and again at the end of the trial (day 21).

Results:
Survivability & Gastrointestinal Persistence:
Initial testing reported that Lactobacillus fermentum was present in the intestinal tract of only 4 of the 16 test subjects. At the end of the trial, fecal samples revealed that the GI tract of all 16 test subjects were colonized with ME-3. Furthermore, testing also revealed that ingesting goats’ milk fermented with Lactobacillus fermentum ME-3 resulted in a doubling of live ME-3 bacteria in the intestinal tract.

These results provide two important pieces of data:

a) When taken orally,  Lactobacillus Fermentum ME-3 survives transit through stomach, which means it does not get killed when exposed to strong stomach acids.

b) When orally ingested  Lactobacillus Fermentum ME-3 arrives in the intestinal tract, the bacteria are able to adhere to the mucosal lining and grow/multiply as evidenced by doubling the concentration of live ME-3 bacteria after 21 days.

Reduction of Cardiovascular Risks:
Free radical damage to lipoproteins (oxidized LDL-cholesterol) can ultimately damage cells that line the arteries, resulting in plaque build-up and atherosclerosis, which is one of the primary causes of cardiovascular disease.  Lactobacillus Fermentum ME-3’s antioxidant activity resulted in a substantial decrease in oxidized LDL- cholesterol.

Increased Antioxidant Protection:

a) The ME-3 test subjects exhibited a substantial reduction in urinary levels of 8- isoprostanes (8-EPI) which is recognized as one of the most reliable ways of measuring oxidative stress.

b) One of the most significant findings was that oral ingestion of ME-3 resulted in a substantial improvement in the systemic ratio of reduced (active) glutathione to oxidized (inactive) glutathione, which indicates a significant improvement in antioxidant protection throughout the entire body.

c) Significant increase in Total Antioxidant Activity (TAA), which also indicates an improvement in both cellular and whole body antioxidant activity.

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