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Perfect Pass Prebiotic Research

Perfect Pass Prebiotic is pure, easy-to-take, soluble fiber that is made from guar gum seeds. These probiotics have the added advantage of being partially hydrolyzed – i.e. PHGG – so that the speed of the fermentation process that occurs in the gut is reduced dramatically. This makes it one of the only probiotics that can be tolerated by even the most sensitive individuals. Additionally, Perfect Pass Prebiotic does not encourage growth of bad bacteria and can be safely taken by those who suffer with SIBO.

Here is a list of research articles showing the positive effects of the one ingredient, guar gum contained Perfect Pass Prebiotics.

Sevinc Al, et al.
Improvement of colonic healing by preoperative oral partially hydrolyzed guar gum in rats which underwent preoperative radiotherapy.
Journal of Drug Targeting. 22:262-268 (1014)

Ishihara N, et al.
Physilogical effect and applications of partially hydrolyzed guar gum.
Luminacoids 17:11-18. (2013)

Paul SP, et al.
Challenges in Management of Irritable Bowel Syndrome in Children.
Ind Pediatr 50: 1137-1143. (2013)

Salaria Ammeta, et al.
Prebiotics in the microencapsulating matrix enhance the viability of probiotic Lactobacillus acidophilus LAI.
Int J Fermented Foods 2. 33-45. (2013)

Romano C, et al.
Partially hydrolyzed guar gum in pediatric functional abdominal pain.
World Journal of Gastroenterology, 2013.

Finley J, et al.
Safety Assessment and Caloric Value of Partially Hydrolyzed Guar Gum. J. Agric Food Chem 61, 1756-1771, (2013)

Ohashi Y, et al.
Faecal fermentation of partially hydrolyzed guar gum, J. Funct. Foods. (2012)

Yasukawa, et al.
Partially hydrolyzed guar gum affects the expression of genes involved in host defense functions and cholesterol absorption in colonic
mucosa of db/db male mice, J. Clin. Biochem. Nutr. (2012)

Furnari M, et al.
Efficay of partially hydrolyzed guar gum in reducing methane excreation and clinical manifestation of subjects suffering from
irritable bowel syndrome. Gastroenterology Abs Sa2058. (2012)

Ishihara N, et al.
Normalization of evacuation on the saline in a nursing home for elderly by partially hydrolyzed guar gum. (2012)

Maeda H, et al.
Partially hydrolyzed guar gum intake ameliorates constipation, improves nutritional status and reduces indoxylsulfuric
acid in dialysis patients. Kidney Research and Clinical Practice 31, A53. (2012)

Prasad PS, et al.
Stool Consistency and Abdominal Pain in Irritable Bowel Syndrome May Be Improved by Partially Hydrolysed Guar Gum.
Journal of Pediatric Gastroenterology & Nutrition: 53: 582-583. (2011)

Furnari M, et al.
Clinical trial: the combination of rifaximin with partially hydrolysed guar gum is more effective than rifaximin alone in eradicating
small intestinal bacterial overgrowth, Aliment. Pharmacol. Ther. (2010)

Ustunda G, et al.
Can partially hydrolyzed guar gum be an alternative to lactulose in treatment of childhood constipation?, Turk. J. Gastroenterol. (2010)

Kuo DC, et al.
Partially hydrolyzed guar gum supplement reduces high-fat diet increased blood lipids and oxidative stress and ameliorates FeC13-
induced acute arterial injury in hamsters, J. Biomed. Sci. (2009)

Takahashi T, et al.
Hydrolyzed guar gum decreases postprandial blood glucose and glucose absorption in the rat small intestine, Nutr Res. (2009)

Lluch A, et al.
Short-term appetite-reducing effects of a low-fat dairy product enriched with PHGG. Food Quality and Preference 21. (2009)

Atila K, et al.
Partially hydrolyzed guar gum attenuates the severity of pouchitis in a rat model of ilea) J pouch-anal anastomosis, Dig. Dis. Sci. (2009)

Yoon S-J, et al.
Chemical and physical properties, safety and application of partially hydrolized guar gum as dietary fiber, J. Clin. Biochem. Nutr. (2008)

Alam NH, et al.
Efficacy of partially hydrolyzed guar gum-added oral rehydration solution in the treatment of severe cholera in adults, Digestion (2008)

Nakamura, S, et al.
Suppressive effect of partially hydrolyzed guar gum on transitory diarrhea induced by ingestion of maltitol and lactitol in healthy humans.
European Journal of Clinical Nutrition. 2007.

Maenaka, T, et al.
Effects of partially hydrolyzed guar gum on postprandial blood glucose level and disaccharidase, J.JSMUFF, 4, 3, pp195-201, 2007.

Giannini, E. et al.
Role of partially hydrolyzed guar gum in the treatment of irritable bowel syndrome, Nutrition, (22), pp334-342, 2006

Stewart, M, et al.
Molecular weight of guar gum affect SCFA profile in model intestinal fermentation, Mol. Nutr. Food Res., 50, pp971-976, 2006.

Naito, Y, et al.
Prevention of life style related disease by dietary fiber, J. JSMUFF, 5, pp271-275. 2006.

Naito, Y, et al.
Partially hydrolyzed guar gum down-regulates colonic inflammatory response in dextran sulfate sodium-induced colitis in mice,
J. Nutr. Biochem., 17, pp402-409, 2006.

Cassia Freitas, K, et al.
Partially hydrolyzed guar gum increases intestinal absorption of iron in growing rats with iron deficiency anemia, Clin. Nutr., 25, pp851-858, 2006.

Yoon, SJ ,et al.
Physiological functions of partially hydrolyzed guar gum, J Clin Biochem Nutr., 39, pp134-144, 2006.

Alam, N, et al.
Partially hydrolysed guar gum supplemented comminuted chicken diet in persistent diarrhoea. A randomised controlled trial,
Arch. Dis. Child., 90, pp195-199. 2005.

Parisi, G, et al.
Treatment effects of partially hydrolyzed guar gum on symptoms and quality of life of patients with irritable bowel syndrome.
A multicenter randomized open trial. Dig. Dis. Sci., 50, pp1107-1112, 2005.

Minekus, M, et al.
Effect of partially hydrolyzed guar gum (PHGG) on the bioaccessibility of fat and cholesterol, Biosci. Biotechnol. Biochem., 69, pp932-938. 2005.

Ishihara, N
Sunfiber®, a water soluble dietary fiber. improves intestinal microflora balance, FOOD Style 21 9 (11), pp53-56, 2005. (Japanese)

Pklkas, AM, et al.
Comparison of different fibers for in vitro production of short chain fatty acids by intestinal microflora, J. Med. Food 8 (1), pp1 13-116, 2005.

Yokozawa, T, et al.
Green tea polyphenols and dietary fibre protect against kidney damage in rats with diabetic nephropathy, J. Pharm. Pharmacol., 57, pp773-780, 2005.

Rushidi, TA, et al.
Control of diarrhea by fiber-eriched diet in ICU patients on enteral nutrition: A prospective randomized controlled trial, Clin. Nutr., 23,
pp1344-1352, 2004.

Cihan, A, et al.
Comparison of early postoperative enteral nutrients versus chow on colonic anastomotic healing in normal animals, Eur Surg Res., 36, pp 112-115, 2004.

Bosaeus, I, et al.
Fibre effects of intestinal functions (diarrhoea, constipation and irritable bowl syndrome),
Clin. Nutr. Suppl., 1, pp33-389, 2004.

Suzuki, T, et al.
Ingestion of guar gum hydrolysate, a soluble and fermentable nondigestible saccharide, improves glucose intolerance and prevents
hypertriglyceridemia in rats fed fructose, J. Nutr., 134, pp 1942-1947, 2004.

Trinidad, T, et al.
Glycemic index of Sunfiber (Cyamoposis tetragonolobus) products in normal and diabetic subjects, Int. J. Food Sci. Technol., 39 (10), pp 1093-1098, 2004.

Bar, A, et al.
Reducing the glycemic impact of food. a new role for some dietary fibres, Innovations in Food Technol., Feb, pp34-38, 2004.

Suzuki, T. et al.
Ingestion of guar gum hydrolysate, a soluble and fermentable nondigestible saccharide, improves glucose intolerance and prevents
hypertriglyceridemia in rats fed fructose, J. Nutr., 134, pp 1942-1947, 2004.

Nakao, M, et al.
Usefulness of soluble dietary fiber for the treatment of diarrhea during enteral nutrition in elderly patients, JSPEN, 18 (3), pp 53-57, 2003.

Slavin, JL, et al.
Partially hydrolyzed guar gum: clinical nutrition uses, Nutrition, 19, pp 549-552, 2003.

YeunHwa, G, et al.
Effect of enzyme hydrolyzed guar gum on elevation of blood glucose levels after meal, Medicine ad biology, 147 (2), pp 19-24, 2003.

lshihara, N
Improvement effect of partially hydrolyzed guar gum, Food Style2l, 7 (12), pp 79-82, 2003.

Yamada, K, et al.
Effect of dietary fiber on the lipid metabolism and immune function of aged Sprague-Dawley rats, Biosci. Biotechnol.
Biochem., 67 (2), pp 429-433, 2003.

Nakao, M, et al.
Usefulness of soluble dietary fiber for the treatment of diarrhea during enteral nutrition in elderly patients, Nutrition, 18, pp 35-39, 2002.

Parisi, G, et al.
High-fiber diet supplementation in patients with irritable bowel syndrome (IBS): A multicenter, randomized, open trial comparison between
wheat bran diet and partially hydrolyzed guar gum (PHGG), Dig. Dis. Sci., 47.
pp 1697-1704, 2002.

Nakao, M, et al.
Usefulness of soluble dietary fiber for the treatment of diarrhea during enteral nutrition in elderly patients. Nutrition. 18 (1), pp 35-39, 2002.

Giaccari, S, et al.
Partially hydrolyzed guar gum: a fiber as coadjuvant in the irritable colon syndrome.
Clin Ter. 152 (1), 21-5, 2001.

Spapen, H, et al.
Soluble fiber reduces the incidence of diarrhea in septic patients receiving total enteral nutrition: a prospective, double-blind, randomized, and controlled trial.
Clinical Nutrition 20 (4), pp 301-305, 2001.

Tuohy, K.M., et al.
The prebiotic effects of biscuits containing partially hydrolyzed guar gum and fructo-oligosaccharides — a human volunteer study.
British Journal of Nutrition. 86. pp 341-348, 2001.

Alam, N, et al.
Partially hydrolyzed guar gum-supplemented oral rehydration solution in the treatment of acute diarrhea in children.
Journal of Pediatric Gastroenterology and Nutrition. 31, pp 503-507, 2000.

Ishihara, N, et al.
Preventative effect of partially hydrolyzed guar gum on infection of salmonella enteritidis in young and laying hens. Poultry Science 79, pp 689-697, 2000.

Greenberg, N.A.
The chemical, physical, and physiological properties of partially hydrolyzed guar gum. Novarts Nutr. Corp. AACC 2000 annual meeting. Nov 5-9, 2000.

Tanaka, T, et al.
Effects of rice gruel containing partially hydrolyzed guar gum on human defecation.
Journal of Nutritional Food, 3 (2), pp 45-52, 2000.

Velazquez, M, et al.
Effect of Oligosaccharides and Fibre substitutes on short chain fatty acid production by human faecal microflora.  Anaerobe 6, pp 87-92, 2000.

Sarianom C, et al.
Long-term fiber intervention program: Reduction in enema use at a developmental care facility. Supplement 100(9), pp A-82, 2000.

Yomada, k, et al.
Dietary effect of guar gum and its partially hydrolyzed product on the lipid metabolism and immune function of Sprague-dawley rats.
Biosci. Biotechnol. Biochem, 63 (12), pp 2163-2167, 1999.

Chu, et al.
Chemical and functional properties of partially hydrolyzed guar gum (Sunfiber) as a dietary Fibre.  Innovations in Food Technology. Feb, 1999.

Okazaki,H, et al.
Improvement in defecation by a beverage containing partially hydrolyzed guar gum. Journal of Nutritional Food, 2 (3), 1999.

Hara, H. et al.
Ingestion of guar-gum hydrolysate partially restores calcium absorption in the large intestine lowered by suppression of
gastric acid secretion in rats. British Journal of Nutrition. 81, pp315-321, 1999.

Hara, H, et al.
Ingestion of guar gum hydrolysate, a soluble fiber, increases calcium absorption in totally gastrectomized rats.
American Society for Nutritional Sciences. J Nutr. 107, pp 1340-1348, 1999.

Alam, N.H., et al.
Effects of a partially hydrolyzed guar gum on intestinal absorption of carbohydrate, protein, and fat: a double-blind controlled
study in volunteers. Clinical Nutrition 17, pp 125-129, 1998.

Patrick, P, et al.
Effect of supplements of partially hydrolyzed guar gum on the occurrence of constipation and use of laxative agents.
Journal of the American dietetic association 98 (8), pp 912-914, 1998.

Greenberg, N.A., et al.
Partially hydrolyzed guar gum as a source of fiber. Cereal Foods World. 43 (9).
pp 703-707, 1998.

Heini, A.F., et al.
Effect of hydrolyzed guar fiber on fasting and postprandial satiety and satiety hormones: a double-blind, placebo-controlled trial during
controlled weight loss. International Journal of Obesity. 22. pp 906-909, 1998.

Tsuda, K, et al.
Effect of partially hydrolyzed guar gum on elevation of blood glucose after sugar intake in human volunteers.
Journal of Japanese Association for dietary fiber research. 2 (1), pp 15-22. 1998.

Yamatoya, K, et al.
Effects of hydrolyzed guar gum on cholesterol and glucose in humans. Food Hydrocolloids. 11 (2). pp 239-242, 1997.

Favier, M, et al.
The cholesterol-lowering effect of guar gum is not the result of a simple diversion of bile acids toward fecal excretion.
Lipids, 32 (9), pp 953-959, 1997.

Peters, A.
Addition of hydrolyzed guar to enteral feeding products in type I diabetic patients.
Diabetes Care, 19 (8), pp 899-900, 1996.

Weaver, G, et al.
Dietary guar gum alters colonic Microbial fermentation in azoxymethane-treated rats. American Institute of Nutrition, pp 1979-1991, 1996.

Hara, H, et al.
Increases in calcium absorption with ingestion of soluble dietary fibre, guar gum hydrolysate, depend on the caecum in partially nephrectomized and normal rats.
British Journal of Nutrition. 76, pp 773-784, 1996.

Furuse, M, et al
Effects of partially hydrolyzed guar gum on feeding behavior and crop emptying rate in chicks.  British Poultry Science. 37, pp 223-227, 1996.

Takahashi, IL, et al.
Effect of liquid diets with or without partially hydrolyzed guar gum on intestinal microbial flora and function of rats.  Nutritional Research. 15 (4), pp 527-536, 1995.

Yamatoya, K, et al.
Effect of hydrolyzed guar gum on frequency and feeling of defecation in humans.
Oyo Toshitsu Kagaku. 42 (3), pp 251-257, 1995.

Golay, A, et al.
The effect of a liquid supplement containing guar gum and fructose on glucose tolerance in non-insulin-dependent diabetic patients.
Nutr. Melab Cardiovasc Dis. 5, pp 141-148, 1995.

Takahashi, H, et al.
Influence of partially hydrolyzed guar gum on constipation in women. J. Nutr, Sci. Vitaminol., 40, pp 251-259, 1994.

Takahashi, H, et al
Influence of intact and partially hydrolyzed guar gum on iron utilization in rats fed on iron-deficient diets. Comp. Biochem. Physiol. 109 (1), pp 75-82, 1994.

Okubo, T, et al.
Effects of partially hydrolyzed guar gum intake on human intestinal microflora and its metabolism.  Biosci. Biotech. Biochem., 58 (8), pp 1364-1369, 1994.

Homman, H, et al.
Reduction in diarrhea incidence by soluble fiber in patients receiving total or supplemental eternal nutrition.
Journal of Parenteral and External Nutrition. 18 (6), pp 486-490, 1994.

Vandeven, M, et al.
Effects of liquid preloads with difference fructose/fibre concentrations on subsequent food intake and ratings or hunger in women.
Appetite, 23, pp 139-146, 1994.

Takahashi, H, et al.
Protein and energy utilization of growing rats fed on the diets containing intact or partially hydrolyzed guar gum.
Comp. Biochem. Physiol. 107A (1), pp255-260. 1993.

Yamatoyo, K, et al.
Effects of partially hydrolyzed guar gum on postprandial plasma glucose and lipid levels in humans.  Nippon Eiyo Syokuryo Gakkaishi. 46 (3). pp 199-203. 1993.

Meier, R, et al.
Effect of a liquid diet with and without soluble fiber supplementation on intestinal transit and cholecystokinin release in volunteers.
Journal of Parenteral and Enteral Nutrition, 17, pp 231-236, 1993.

Takahashi, H, et al.
Effect of partially hydrolyzed guar gum on fecal output in human volunteers.
Nutritional Research, 13, pp 649-657, 1993.

Lampe, J, et al.
Gastrointestinal effects of modified guar gum and soy polysaccharide as part of an enteral formula diet.
Journal of Parenteral and Enteral Nutrition. 16 (6), pp 538-546, 1992.

Ide, T, et al.
Hypolipidemic effects of guar gum and its enzyme hydrolysate in rats fed highly saturated fat diets.
Ann Nutr Metlab, 35. pp34-44, 1991.

Takeno, F, et al.
Effect of partially decomposed guar gum on high-cholesterol-fed rats and non-dietary fiber-fed rats.  Research Laboratories, Dainippon Pharmaceutical Co., Ltd, 43 (6),
pp 421-425, 1990.

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Dr. Pamela Nathan DHM September 18, 2016