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Reg’Activ Lactobacillus Fermentum ME-3 Helps Dermatits & Strokes

Lactobacillus Fermentum ME-3  Improvement in Dermatitis and Stroke

Title: Probiotics, Oxidative Stress, Inflammation and Diseases

Publication: 4th Central European Congress on Food. May 15-17, Caveat, Croatia.

Authors: Tiiu Kullisaar, Marika Mikelsaar, Sirje Kaur, Epp Songisepp, Kersti Zilmer, Pirje Jutt, Aet Lukmann, Jaak Maaroos, Jaak Kals, and Mihkel Zilmer

Part 1: Atopic Dermatitis:
11 patients with atopic dermatitis, ages 20-42 years old, randomized into 2 groups.

During the 3-month trial, 5 patients consumed goats’ milk with ME-3 while 6 people acted as placebo controls.

Results: Patients with atopic dermatitis generally have abnormalities of their glutathione-system along with increased oxidative stress, inflammation and often impaired skin membrane barrier function.

Individuals receiving ME-3 experienced significant improvements in skin condition, blood markers and in self-assessment rating scores.

Dermatitis Research on benefits of Lactobacillus Fermentum ME-3

Dermatitis Research on benefits of Lactobacillus Fermentum ME-3 Results

Part 2: Brain Stroke:
21 patients (ages 71-89) who had experienced a brain stroke sometime between 8 to 22 days earlier were randomly divided into 2 groups.

Subjects consumed either 3 capsules of ME-3 twice daily or 3 placebo capsules twice daily for time that ranged from 10 days to 3 weeks.

Patients were evaluated on the Functional Independence Measure inventory (FIM) and on the Scandinavian Stroke Scale (SSS).

Stroke patients consuming ME-3 exhibited significant improvements in both the Scandinavian Stroke Scale and the Functional Independence Measure inventory.

Stroke patients also experienced impressive improvements in the following blood markers: oxidized LDL-cholesterol, glutathione levels & ratio of reduced to oxidized glutathione, total antioxidant capacity, paraoxonase enzyme activity as well as reductions in markers of inflammation and free radical damage.

Stroke Research on benefits of Lactobacillus Fermentum ME-3

Stroke Research Results on benefits of Lactobacillus Fermentum ME-3

Part 3: Assay of Blood & Urine Markers:
15 healthy volunteers, ages (40-65). After a 2-week introductory period, the volunteers were randomized into a double-blind, placebo-controlled, crossover trial.

Individuals ingested kefir with ME-3 or placebo kefir for two weeks.

After a 3-week wash-out period, new blood & urine samples were taken and then subjects crossed over to take the alternate regime for an additional 2 weeks.

Results: Volunteers taking ME-3 experienced improvements in all blood and urine markers evaluated compared to controls.
Doses of Lactobacillus fermentum ME-3 used in the Human Clinical Trials

In most of the studies where the test subjects were taking capsules containing Lactobacillus fermentum ME-3, the dose was one billion bacteria per day.

In the brain stroke study, the dose was 6 billion per day.

Kefir: The probiotic doses in kefir are substantially higher, providing approximately 20-30 billion bacteria per day.
Even though the daily dose of ME-3 is much higher in the kefir delivery method compared to the dose of ME-3 in capsules, it is interesting to note that the magnitude of the beneficial changes (oxidized LDL-cholesterol, PON enzyme activity and total antioxidant status) are quite similar in the kefir trials compared to the capsule trials.

This indicates large doses (20- 30 billion) do not provide additional benefit beyond moderate doses containing several billion bacteria.

The Reg’Activ formulas contain from 4 to 6 billion cfu of ME-3 per day.

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