Genova Lab Intestinal Permeability Assessment
Genova Lab IP assessment analyzes urine for the clearance of two non-metabolized
sugars, lactulose and mannitol to identify
leaky gut syndrome
and malabsorption. The assessment directly measures
the ability of the two nonmetabolized sugar molecules
to permeate the intestinal mucosa.
Mannitol is easily absorbed and serves as a marker of
transcellular uptake, while lactulose is only slightly
absorbed and serves as a marker for mucosal integrity.
To perform the test, one mixes premeasured
amounts of lactulose and mannitol and drinks the
challenge substance. The test measures the amount of
lactulose and mannitol recovered in a urine sample over
the next 6 hours.
The small intestine has the paradoxical dual function of
being a digestive/ absorptive organ for nutrients as well
as a powerful barrier against the excessive absorption of
bacteria, food antigens and large molecules. Increased
permeability or leaky gut of the intestinal mucosal barrier can swell
the number of toxins & antigens entering the bloodstream
and lead to an overly sensitized immune system in some
individuals.
Decreased permeability, on the other hand,
appears as a fundamental cause of malnutrition,
malabsorption and failure to thrive. A number of clinical
disorders are associated with both conditions.
Sample Report for leaky gut syndrome evaluation
*Labs are not processed from New York state.
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