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Crohn's Disease- Pathophysiology and Conventional and Alternative Treatment Options

Table 2. Signs and Symptoms of Crohn's Disease and Ulcerative Colitis

Sign/Symptom	Crohn's Disease	Ulcerative Colitis
Area of intestinal tract affected	Lower ileum most common but can flare up anywhere, including the colon; "patches" of normal tissue between affected areas: can affect entrie intestinal wall	Any part of inner most lining of colon, continues with no "patches" of normal tissue
Diarrhea	Typically four or more episodes per day	Typically four or more episodes per day
Abdominal pain/cramping	Moderate to severe abdominal tenderness in right lower quadrant	Mild tenderness, lower abnominal cramping
Blood in stool	Present; amount depends on disease severity	Present; amount depends on disease severity
Fatigue	Result of excessive blood loss, anemia, and poor nutrient absorption	Result of excessive blood loss and anemia
Fever	Low-grade in severe cases	Low-grade in severe cases
Physical examination	Peritoneal irritation, abdominal or pelvic mass	Rectal exam may show peri-anal irritation, fissures, hemorrhoids, fistulas, and abscesses
Weight loss/anorexia	Weight loss and anorexia common due to poor digestion and intestinal absorption	Weight loss in more severe cases
Appetite	Often decreased during periods of disease exacerbation	Often decreased during periods of disease exacerbation
Risk of colon cancer	Increased	Increased

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