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Also known as microscopic colitis, Collagenous Colitis and Lymphocytic Colitis, show no sign of inflammation on the surface of the colon during a colonoscopy or flexible sigmoidoscopy, two tests that allow a doctor to view the inside of your large intestine. A biopsy is required to make a diagnosis due to the slight visibility of the inflammation. The biopsy involves removing a small piece of tissue from the lining of the intestine during a colonoscopy or flexible sigmoidoscopy.
People with Lymphocytic Colitis are also most diagnosed on those between 60 and 80 years of age. Lympohcytic Colitis is equally diagnosed between men and women.
Collagenous Colitis shows an irregularly large band of protein, known as collagen, inside the lining of the colon. The bands vary in thickness; so tissue samples from multiple areas of the colon may need to be examined.
With Lymphocytic Colitis, tissue samples are characterized by an increase of white blood cells, known as lymphocytes, between the cells lining the colon. The collagen is not affected.
Normally, lifestyle changes are implemented as treatment first. Some recommendations include decreasing fat intake, removing foods that contain caffeine and lactose, and steering clear from over-the-counter pain relievers (e.g. ibuprofen, aspirin, etc.).
If a lifestyle change is not effective, medications can help control symptoms.
A medical treatment often begins with prescribing anti-inflammatory medications, such as mesalamine (Rowasa or Canasa) and sulfasalazine (Azulfidine), to reduce swelling.
Steroids, including budesonide (Entocort) and prednisone, are used to reduce inflammation as well. However, steroids are normally only used to control sudden diarrhea. Long-term use of steroids is not recommended due to side effects such as bone loss and high blood pressure.
Anti-diarrheal medications such as bismuth subsalicylate (Pepto Bismol), diphenoxylate atropine (Lomotil), and loperamide (Imodium) may provide short-term relief.
Immunosuppressive agents, such as azathioprine (Imuran), reduce the inflammation but are rarely needed.
For severe cases of Collagenous Colitis and Lymphocytic Colitis that have not responded to medication, surgery may be required to remove all or part of the colon. However, the surgical method is rarely recommended.
Collagenous Colitis and Lymphocytic Colitis do not increase a person's risk of getting colon cancer.
Source: NIH Publication No. 06-5036, Collagenous Colitis and Lymphocytic Colitis, January 2006